Hjerte-magnetisk resonans (HMR) er en stråle-fri scanningsteknik, der giver den bedste standard til evaluering af hjertets anatomi, funktion og endda vævssammensætning. I RESILIENCE-forsøget anvendes HMR som den primære metode, og patienter vil i forsøgspersioden modtage 3 af disse scanninger.
RESILIENCE-forsøget er et multinationalt, prospektivt, proof-of-concept fase II, dobbeltblindet, sham-kontrolleret, randomiseret klinisk forsøg (RCT) til at evaluere effekten og sikkerheden af fjern iskæmisk prækonditionering (RIC) hos patienter med Lymfom der modtager kræftbehandling med antracykliner. Forsøgsdeltagelse forudsætter ≥5 planlagte kemoterapibehandlinger.
There is a strong need to identify (bio)markers that can detect early stages of anthracycline-induced cardiotoxicity (AIC). In this editorial, 2 RESILIENCE researchers present the current state of the art of the field. They discuss data from al original paper published in the same issue of the journal by Bonny
By using a highly translatable large-animal model, this work shows that cumulative exposure to anthracycline results in an irreversible damage to the heart microcirculation. The microcirculation injury is observed even before overt left ventricular cardiac systolic dysfunction (surrogate for overt cardiotoxicity) is present. Cardiac microcirculation damage is associated with poor
Editorial article highlighting the strong potential of remote ischemic conditioning to prevent anthracycline-induced cardiotoxicity. This intervention will be tested within RESILIENCE project.
Serial cardiac magnetic resonance (CMR) evaluation of a highly translatable large-animal (pig) model of anthracycline-induced cardiotoxicity (AIC) shows that cumulative exposure to anthracyclines results in significantly reduced left ventricular ejection fraction and extensive mitochondrial fragmentation. Remote Ischemic Conditioning applied before each anthracycline cycle preserved cardiac contractility and left ventricular ejection
