There is a strong need to identify (bio)markers that can detect early stages of anthracycline-induced cardiotoxicity (AIC). In this editorial, 2 RESILIENCE researchers present the current state of the art of the field. They discuss data from al original paper published in the same issue of the journal by Bonny Ky´s team, showing that paraoxonase-1 (PON-1) appears a potential circulating biomarker of AIC in breat cancer patients. In this editorial, RESILIENCE project is presented as one of the most promising ongoing endeavors in the quest for the identification of sensitive markers of early AIC.