RESILIENCE helps you survive cancer with a strong heart

Cardiac Magnetic Resonance

Cardiac magnetic resonance is a technique without radiation, which is considered the gold-standard for the evaluation of cardiac anatomy, function and even tissue composition.

The RESILIENCE trial will use Cardiac Magnetic Resonance (CMR) as the main outcome measure methodology, and patients enrolled in the trial will undergo 3 scans across the duration of the study. Anthracycline-induced cardiotoxicity (AIC) will be diagnosed based on changes in left ventricular systolic function as evaluated by CMR.

Taking advantage of the large population recruited in the RESILIENCE trial across Europe, a novel CMR methodology that can identify early AIC will be validated. The new methodology is based on multiparametric CMR imaging, mainly T2 mapping. In experimental models, T2 mapping is the earliest parameter altered in the AIC process. Patients enrolled in RESILIENCE will undergo a comprehensive contrast-enhanced CMR study, including cardiac anatomy, function, techniques for myocardial strain assessment (fast-strain-encoded-SENC-, tagging, and feature tracking), quantitative perfusion, and T1/T2 mapping.
Cardiac Magnetic Resonance in RESILIENCE
Real Magnetic Resonance Imaging Equipment (source: Centro Nacional de Investigaciones Cardiovascular (CNIC))

Despite CMR is universally recognized as the gold standard technique for the evaluation of the heart, it is not universally used. One of the main reasons for this is that image acquisition takes a long time (45 to 60 min for a comprehensive protocol). This long duration results in low availability of the equipment in the hospitals, and also in patient´s discomfort. Members of the RESILIENCE consortium have developed a revolutionary CMR technique allowing a massive reduction in the time of scan. This new 3D single breath-hold CMR methodology is named Enhance SENSE by Static Outer volume Subtraction (ESSOS) This novel methodology might revolutionize the field of CMR and increase patient access to this technique. In addition, this technique will reduce patient discomfort, something very relevant for vulnerable populations, such as the elderly, the pediatric. The RESILIENCE project will validate this new methodology (as compared to the currently used).

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Are you a patient participating in RESILIENCE? Here you will find useful information about the details of your participation, activities specifically designed for you. You will also be able to contact RESILIENCE researchers.

In accordance with the provisions of Regulation (EU) 2016/679 on the protection of personal data of natural persons (GDPR), the personal information you have provided will be incorporated into the data processing systems of the Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.) for the purpose of attending your registration application in the restricted area for patients participating in the RESILIENCE study. The legal basis for processing your personal data for this purpose is your explicit consent. Your personal data will not be disclosed to any recipients other than those to whom you authorise or when required by law to do so. You may exercise your rights of access, right to rectification, to object, to erasure, to restriction of processing, data portability and not to be subject to automated individual decision-making. To exercise these rights, as well as to obtain additional information about the processing of your personal data, you can consult the following link Terms and Conditions