The RESILIENCE project develop a novel healthcare intervention (Remote Ischemic Conditioning, RIC) aimed at reducing the prevalence of chronic heart failure in cancer survivors.
Remote ischemic conditioning (RIC) is a phenomenon by which brief, reversible episodes of occlusion and re-occlusion in one organ (e.g. an arm) render remote organs resistant to injury.
Cardiac magnetic resonance (CMR) it is a technique without radiation, which is considered the gold-standard for the evaluation of cardiac anatomy, function and even tissue composition. The RESILIENCE trial will use CMR as the main outcome measure methodology, and patients enrolled in the trial will undergo 3 scans across the duration of the study.
Multinational, prospective, proof of concept phase II, double-blinded, sham-controlled, randomized clinical trial (RCT) to evaluate the efficacy and safety of Remote Ischaemic Conditioning (RIC) in Lymphoma patients receiving anthracyclines. Patients scheduled to undergo ≥5 chemotherapy cycles will be eligible.
The RESILIENCE trial will use Cardiac Magnetic Resonance (CMR) as the main outcome measure methodology, and patients enrolled in the trial will undergo 3 scans across the duration of the study. Anthracycline-induced cardiotoxicity (AIC) will be diagnosed based on changes in left ventricular systolic function as evaluated by CMR.
Despite CMR is universally recognized as the gold standard technique for the evaluation of the heart, it is not universally used. One of the main reasons for this is that image acquisition takes a long time (45 to 60 min for a comprehensive protocol). This long duration results in low availability of the equipment in the hospitals, and also in patient´s discomfort. Members of the RESILIENCE consortium have developed a revolutionary CMR technique allowing a massive reduction in the time of scan. This new 3D single breath-hold CMR methodology is named Enhance SENSE by Static Outer volume Subtraction (ESSOS) This novel methodology might revolutionize the field of CMR and increase patient access to this technique. In addition, this technique will reduce patient discomfort, something very relevant for vulnerable populations, such as the elderly, the pediatric. The RESILIENCE project will validate this new methodology (as compared to the currently used).
Cookie | Duration | Description |
---|---|---|
cookielawinfo-checkbox-analytics | 11 months | This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Analytics". |
cookielawinfo-checkbox-functional | 11 months | The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional". |
cookielawinfo-checkbox-necessary | 11 months | This cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary". |
cookielawinfo-checkbox-others | 11 months | This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other. |
cookielawinfo-checkbox-performance | 11 months | This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Performance". |
viewed_cookie_policy | 11 months | The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data. |