Remote ischaemic conditioning: defining critical criteria for success—report from the 11th Hatter Cardiovascular Workshop

The Hatter Cardiovascular Institute biennial workshop, originally scheduled for April 2020 but postponed for 2 years due to the Covid pandemic, was organised to debate and discuss the future of Remote Ischaemic Conditioning (RIC). This evolved from the large multicentre CONDI-2–ERIC–PPCI outcome study which demonstrated no additional benefit when using RIC in the setting of […]

RESILIENCE clinical trial

Our RESILIENCE team has prepared this video in which we explain how the therapy is randomized for the RESILIENCE clinical trial. For this procedure, we will use the electronic case report form (e-CRF), a software that will assign one of the corresponding therapies randomly. The research team will access to the e-CRF via the website […]

RESILIENCE TALKS – Leaders of the Future

Interview with Alberto López-García – Fundación Jiménez Díaz University Hospital (IIS-FJD) Alberto is a young researcher leading an important part of the project. Alberto represents the young community of the project. One of the goals of RESILIENCE is to identify the European leaders of the future. Could you tell us a bit about yourself? I […]

The Quest for an Early Marker of
Anthracycline-Induced Cardiotoxicity

There is a strong need to identify (bio)markers that can detect early stages of anthracycline-induced cardiotoxicity (AIC). In this editorial, 2 RESILIENCE researchers present the current state of the art of the field. They discuss data from al original paper published in the same issue of the journal by Bonny Ky´s team, showing that paraoxonase-1 […]

Coronary microcirculation damage in anthracycline cardiotoxicity

By using a highly translatable large-animal model, this work shows that cumulative exposure to anthracycline results in an irreversible damage to the heart microcirculation. The microcirculation injury is observed even before overt left ventricular cardiac systolic dysfunction (surrogate for overt cardiotoxicity) is present. Cardiac microcirculation damage is associated with poor clinical outcome in general, and […]

CNIC coordina RESILIENCE, un proyecto diseñado para reducir la insuficiencia cardíaca en pacientes con cancer

La Comisión Europea, a través del programa H2020 “Salud, Cambio Demográfico y Bienestar”, ha designado al Centro Nacional de Investigaciones Cardiovasculares (CNIC) como coordinador de RESILIENCE (REmote iSchemic condItioning in Lymphoma PatIents REceiving ANthraCyclinEs), un ambicioso proyecto especialmente diseñado para desarrollar una nueva intervención médica destinada a reducir la prevalencia de la insuficiencia cardíaca crónica […]

Remote ischaemic preconditioning ameliorates anthracycline-induced cardiotoxicity and preserves mitochondrial integrity

Serial cardiac magnetic resonance (CMR) evaluation of a highly translatable large-animal (pig) model of anthracycline-induced cardiotoxicity (AIC) shows that cumulative exposure to anthracyclines results in significantly reduced left ventricular ejection fraction and extensive mitochondrial fragmentation. Remote Ischemic Conditioning applied before each anthracycline cycle preserved cardiac contractility and left ventricular ejection fraction in long-term CMR exams. […]

RESILIENCE, a project to reduce the prevalence of heart failure in cancer survivors

Cancer patients are a vulnerable population prone to develop cardiovascular complications. Among other factors, some anticancer therapies can induce adverse cardiovascular effects. Every year, more than 3 million Europeans receive aCancer patients are a vulnerable population prone to develop cardiovascular complications. Among other factors, some anticancer therapies can induce adverse cardiovascular effects. Every year, more […]