Remote ischaemic conditioning: defining critical criteria for success—report from the 11th Hatter Cardiovascular Workshop

The Hatter Cardiovascular Institute biennial workshop, originally scheduled for April 2020 but postponed for 2 years due to the Covid pandemic, was organised to debate and discuss the future of Remote Ischaemic Conditioning (RIC). This evolved from the large multicentre CONDI-2–ERIC–PPCI outcome study which demonstrated no additional benefit when using RIC in the setting of […]

The Quest for an Early Marker of
Anthracycline-Induced Cardiotoxicity

There is a strong need to identify (bio)markers that can detect early stages of anthracycline-induced cardiotoxicity (AIC). In this editorial, 2 RESILIENCE researchers present the current state of the art of the field. They discuss data from al original paper published in the same issue of the journal by Bonny Ky´s team, showing that paraoxonase-1 […]

Coronary microcirculation damage in anthracycline cardiotoxicity

By using a highly translatable large-animal model, this work shows that cumulative exposure to anthracycline results in an irreversible damage to the heart microcirculation. The microcirculation injury is observed even before overt left ventricular cardiac systolic dysfunction (surrogate for overt cardiotoxicity) is present. Cardiac microcirculation damage is associated with poor clinical outcome in general, and […]

Remote ischaemic preconditioning ameliorates anthracycline-induced cardiotoxicity and preserves mitochondrial integrity

Serial cardiac magnetic resonance (CMR) evaluation of a highly translatable large-animal (pig) model of anthracycline-induced cardiotoxicity (AIC) shows that cumulative exposure to anthracyclines results in significantly reduced left ventricular ejection fraction and extensive mitochondrial fragmentation. Remote Ischemic Conditioning applied before each anthracycline cycle preserved cardiac contractility and left ventricular ejection fraction in long-term CMR exams. […]