The RESILIENCE project develop a novel healthcare intervention (Remote Ischemic Conditioning, RIC) aimed at reducing the prevalence of chronic heart failure in cancer survivors.
Remote ischemic conditioning (RIC) is a phenomenon by which brief, reversible episodes of occlusion and re-occlusion in one organ (e.g. an arm) render remote organs resistant to injury.
Cardiac magnetic resonance (CMR) it is a technique without radiation, which is considered the gold-standard for the evaluation of cardiac anatomy, function and even tissue composition. The RESILIENCE trial will use CMR as the main outcome measure methodology, and patients enrolled in the trial will undergo 3 scans across the duration of the study.
Multinational, prospective, proof of concept phase II, double-blinded, sham-controlled, randomized clinical trial (RCT) to evaluate the efficacy and safety of Remote Ischaemic Conditioning (RIC) in Lymphoma patients receiving anthracyclines. Patients scheduled to undergo ≥5 chemotherapy cycles will be eligible.
This is an ideal setting for a controlled trial in order to reduce the chances of confounders. NHL patients are especially vulnerable to anthracycline-induced cardiotoxicity. Mean age of NHL diagnosis is in the eight decade of life, a time where cardiovascular comorbidities are frequent, increasing the likelihood of post-therapy heart failure. Another important rationale for choosing this cancer type as a target of this project is that there is a balance in the incidence of NHL diagnoses across genders (60% male/40%female). There is no conclusive information about gender differences in cancer therapy-induced cardiotoxicity. One main reason for this lack of information is that most of the studies evaluating the incidence of cardiotoxicity have been done in breast cancer patients, a malignancy with a very low representation of male patients. Our aim is to extend the results of the project beyond NHL to all cancer patients treated with anthracyclines
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