Newsletter N.1, December 2021

This Project has received funding from the European Union´s Horizon 2020 research and innovation programme under grant agreement No 945118

Evolution of

Resilience

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June 21st 2021

Progress update

  • Kick off meeting of the project: June 21st 2021
  • Governing Bodies instituted

RESILIENCE´s Scientific Advisory Board (SAB)

  • All approvals (ethics committees, regulatory, etc) ready to start recruitment in Spain
  • Remote ischemic conditioning devices ready
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Scientific

Advances

Remote ischaemic preconditioning ameliorates anthracycline-induced cardiotoxicity and preserves mitochondrial integrity.

The article demonstrating the strong effect of remote ischemic conditioning in preventing anthracycline-induced cardiotoxicity in a large animal model is already published.

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Protection from cardiotoxicity of cancer chemotherapy: a novel target for remote ischaemic conditioning?

An accompanying editorial from a member of Prof Heusch highlights the strong potential of this novel intervention, something that will be tested in RESILIENCE.

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Coronary microcirculation damage in anthracycline cardiotoxicity

A new article from members of the consortium shows that anthracyclines induce a permanent damage to the microcirculation of the heart. By using a highly translatable large-animal model, this work shows that cumulative exposure to anthracycline results in an irreversible damage to the heart microcirculation. Cardiac microcirculation damage is associated with poor clinical outcome in general, and thus the present findings might partially explain the high incidence of cardiovascular adverse outcomes in cancer survivors even in the absence of overt cardiotoxicity.

RESILIENCE CMR

Protocol includes the comprehensive evaluation of the microcirculation and thus the cardioprotection afforded by remote ischemic conditioning in this compartment (cardiac microcirculation) will be evaluated in a clinical setting.

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Latest

videos

Novel mitochondria-targeted therapies for cancer treatment-induced cardiotoxicity

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